The Use of Preoperative Osmotic Laxatives to Improve Recovery of Bowel Function After Robotic-assisted Urologic Surgery

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY

Minimally-invasive surgery, either laparoscopic or robotic, is commonly used in urology. Several urologic procedures including prostatectomy, radical nephrectomy, and partial nephrectomy are now commonly performed robotically. Patients undergoing these procedures often have delayed return of bowel function and persistent gastrointestinal symptoms including nausea/vomiting, abdominal distension, and bloating for several days to weeks after surgery. Postoperative stool softeners and laxatives are routinely used in an effort to minimize these symptoms, with varying degrees of success. The aim of this study will be to evaluate whether the use of a preoperative osmotic laxative will be beneficial in improving recovery of bowel function and alleviating postoperative gastrointestinal complaints in patients undergoing these procedures. Patients will be randomized to either receive or not receive three days of polyethylene glycol (PEG, also known as MiraLAX) on the three days before surgery. Patients in both groups will receive the same postoperative bowel regimen including scheduled PEG both in the hospital and upon discharge until first bowel movement. Patients will be given a questionnaire and diary to record their postoperative gastrointestinal symptoms and time to first bowel movement. These questionnaires and diaries will then be analyzed to determine differences in time to first bowel movement and gastrointestinal complaints during their recovery from surgery.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 30
Maximum Age: 100
Healthy Volunteers: t
View:

• Patients 30 years or older undergoing robotic-assisted laparoscopic radical prostatectomy, transperitoneal radical nephrectomy, or transperitoneal partial nephrectomy

Locations
United States
Iowa
University of Iowa Hospitals & Clinics
RECRUITING
Iowa City
Contact Information
Primary
Chad Tracy, MD
chad-tracy@uiowa.edu
+1 319 335 8056
Time Frame
Start Date: 2023-06-01
Estimated Completion Date: 2026-03-03
Participants
Target number of participants: 240
Treatments
No_intervention: Control
Do not receive polyethylene glycol before surgery
Experimental: Intervention
Receive polyethylene glycol before surgery
Sponsors
Leads: Chad R. Tracy

This content was sourced from clinicaltrials.gov